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dynamin 2 inhibitor (dynasore  (Enzo Biochem)

 
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    Structured Review

    Enzo Biochem dynamin 2 inhibitor (dynasore
    Endocytosis mechanism of Ad in combination with HDACi: ( a ) U343 cells were pretreated with ( a ) <t>dynamin</t> <t>2</t> inhibitor (dynasore—40 μM), ( b ) clathrin inhibitor (CPZ—5 μM), or ( c ) caveolin inhibitor (genistein—37 μM) for 45 min. Subsequently, the cells were treated with dAd/GFP, dAd/GFP+SBHA, or dAd/GFP+MS-275. At 24 h post transduction, cells were analyzed for GFP expression by using the IncuCyte ® Live-Cell Analysis System (Sartorius). The data are representatives of three independent experiments performed in triplicate. Representative images are shown. Original magnification: ×40. Bars represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001.
    Dynamin 2 Inhibitor (Dynasore, supplied by Enzo Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dynamin+2+inhibitor+(dynasore/dynamin+2+inhibitor++dynasore/pmc08616263-58-5-10
    Average 90 stars, based on 1 article reviews
    dynamin 2 inhibitor (dynasore - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment"

    Article Title: GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment

    Journal: Cells

    doi: 10.3390/cells10112811

    Endocytosis mechanism of Ad in combination with HDACi: ( a ) U343 cells were pretreated with ( a ) dynamin 2 inhibitor (dynasore—40 μM), ( b ) clathrin inhibitor (CPZ—5 μM), or ( c ) caveolin inhibitor (genistein—37 μM) for 45 min. Subsequently, the cells were treated with dAd/GFP, dAd/GFP+SBHA, or dAd/GFP+MS-275. At 24 h post transduction, cells were analyzed for GFP expression by using the IncuCyte ® Live-Cell Analysis System (Sartorius). The data are representatives of three independent experiments performed in triplicate. Representative images are shown. Original magnification: ×40. Bars represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001.
    Figure Legend Snippet: Endocytosis mechanism of Ad in combination with HDACi: ( a ) U343 cells were pretreated with ( a ) dynamin 2 inhibitor (dynasore—40 μM), ( b ) clathrin inhibitor (CPZ—5 μM), or ( c ) caveolin inhibitor (genistein—37 μM) for 45 min. Subsequently, the cells were treated with dAd/GFP, dAd/GFP+SBHA, or dAd/GFP+MS-275. At 24 h post transduction, cells were analyzed for GFP expression by using the IncuCyte ® Live-Cell Analysis System (Sartorius). The data are representatives of three independent experiments performed in triplicate. Representative images are shown. Original magnification: ×40. Bars represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Techniques Used: Transduction, Expressing

    Related Articles

    Negative Control:

    Article Title: GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment
    Article Snippet: .. U343 cells were pretreated with dynamin 2 inhibitor (dynasore—40 μM, Enzo Life Sciences, Farmingdale, NY, USA), clathrin inhibitor (CPZ—5 μM, Enzo Life Sciences), or caveolin inhibitor (genistein—37 μM, Enzo Life Sciences) for 45 min, along with PBS as a negative control. ..

    Solvent:

    Article Title: The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.
    Article Snippet: Primary human mammary epithelial cells (HMEC) were culture in EBM-2 Basal Medium (Cambrex Inc., East Rutherford, NJ). .. The following standard treatment groups were employed in our study: dimethyl sulfoxide (DMSO; Sigma-Aldrich Inc.) as a solvent control; 1 mM PP2 (Src tyrosine kinase inhibitor; EMB Biosciences, Inc.; La Jolla, CA); 1 mM AG1478 (EGFR tyrosine kinase inhibitor; EMB Biosciences, Inc.); 0.5 mM jasplakinolide (inducer of actin polymerization; Enzo Life Sciences International, Inc.; Plymouth Meeting, PA); 2.5 mM latrunculin A (inhibitor of actin polymerization; Enzo Life Sciences International, Inc.); 50 mg/ml nystatin (disrupts caveolar structure and function; Enzo Life Sciences International, Inc.); 200 mM genistein (disrupts caveolae-mediated PLOS Pathogens | www.plospathogens.org 15 July 2013 | Volume 9 | Issue 7 | e1003463 endocytosis; Enzo Life Sciences International, Inc.), 100 mM Rac1 inhibitor (Rho GTPase inhibitor; Enzo Life Sciences International, Inc.) and 50 mM dynasore (dynamin inhibitor; Enzo Life Sciences International, Inc.) were added 1 h prior to HCMV infection at 37uC with 5% CO2. ..

    Article Title: The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes
    Article Snippet: Primary human mammary epithelial cells (HMEC) were culture in EBM-2 Basal Medium (Cambrex Inc., East Rutherford, NJ). .. The following standard treatment groups were employed in our study: dimethyl sulfoxide (DMSO; Sigma-Aldrich Inc.) as a solvent control; 1 μM PP2 (Src tyrosine kinase inhibitor; EMB Biosciences, Inc.; La Jolla, CA); 1 μM AG1478 (EGFR tyrosine kinase inhibitor; EMB Biosciences, Inc.); 0.5 μM jasplakinolide (inducer of actin polymerization; Enzo Life Sciences International, Inc.; Plymouth Meeting, PA); 2.5 μM latrunculin A (inhibitor of actin polymerization; Enzo Life Sciences International, Inc.); 50 μg/ml nystatin (disrupts caveolar structure and function; Enzo Life Sciences International, Inc.); 200 μM genistein (disrupts caveolae-mediated endocytosis; Enzo Life Sciences International, Inc.), 100 μM Rac1 inhibitor (Rho GTPase inhibitor; Enzo Life Sciences International, Inc.) and 50 μM dynasore (dynamin inhibitor; Enzo Life Sciences International, Inc.) were added 1 h prior to HCMV infection at 37°C with 5% CO 2 . ..

    Control:

    Article Title: The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.
    Article Snippet: Primary human mammary epithelial cells (HMEC) were culture in EBM-2 Basal Medium (Cambrex Inc., East Rutherford, NJ). .. The following standard treatment groups were employed in our study: dimethyl sulfoxide (DMSO; Sigma-Aldrich Inc.) as a solvent control; 1 mM PP2 (Src tyrosine kinase inhibitor; EMB Biosciences, Inc.; La Jolla, CA); 1 mM AG1478 (EGFR tyrosine kinase inhibitor; EMB Biosciences, Inc.); 0.5 mM jasplakinolide (inducer of actin polymerization; Enzo Life Sciences International, Inc.; Plymouth Meeting, PA); 2.5 mM latrunculin A (inhibitor of actin polymerization; Enzo Life Sciences International, Inc.); 50 mg/ml nystatin (disrupts caveolar structure and function; Enzo Life Sciences International, Inc.); 200 mM genistein (disrupts caveolae-mediated PLOS Pathogens | www.plospathogens.org 15 July 2013 | Volume 9 | Issue 7 | e1003463 endocytosis; Enzo Life Sciences International, Inc.), 100 mM Rac1 inhibitor (Rho GTPase inhibitor; Enzo Life Sciences International, Inc.) and 50 mM dynasore (dynamin inhibitor; Enzo Life Sciences International, Inc.) were added 1 h prior to HCMV infection at 37uC with 5% CO2. ..

    Article Title: The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes
    Article Snippet: Primary human mammary epithelial cells (HMEC) were culture in EBM-2 Basal Medium (Cambrex Inc., East Rutherford, NJ). .. The following standard treatment groups were employed in our study: dimethyl sulfoxide (DMSO; Sigma-Aldrich Inc.) as a solvent control; 1 μM PP2 (Src tyrosine kinase inhibitor; EMB Biosciences, Inc.; La Jolla, CA); 1 μM AG1478 (EGFR tyrosine kinase inhibitor; EMB Biosciences, Inc.); 0.5 μM jasplakinolide (inducer of actin polymerization; Enzo Life Sciences International, Inc.; Plymouth Meeting, PA); 2.5 μM latrunculin A (inhibitor of actin polymerization; Enzo Life Sciences International, Inc.); 50 μg/ml nystatin (disrupts caveolar structure and function; Enzo Life Sciences International, Inc.); 200 μM genistein (disrupts caveolae-mediated endocytosis; Enzo Life Sciences International, Inc.), 100 μM Rac1 inhibitor (Rho GTPase inhibitor; Enzo Life Sciences International, Inc.) and 50 μM dynasore (dynamin inhibitor; Enzo Life Sciences International, Inc.) were added 1 h prior to HCMV infection at 37°C with 5% CO 2 . ..

    Infection:

    Article Title: The HCMV gH/gL/UL128-131 complex triggers the specific cellular activation required for efficient viral internalization into target monocytes.
    Article Snippet: Primary human mammary epithelial cells (HMEC) were culture in EBM-2 Basal Medium (Cambrex Inc., East Rutherford, NJ). .. The following standard treatment groups were employed in our study: dimethyl sulfoxide (DMSO; Sigma-Aldrich Inc.) as a solvent control; 1 mM PP2 (Src tyrosine kinase inhibitor; EMB Biosciences, Inc.; La Jolla, CA); 1 mM AG1478 (EGFR tyrosine kinase inhibitor; EMB Biosciences, Inc.); 0.5 mM jasplakinolide (inducer of actin polymerization; Enzo Life Sciences International, Inc.; Plymouth Meeting, PA); 2.5 mM latrunculin A (inhibitor of actin polymerization; Enzo Life Sciences International, Inc.); 50 mg/ml nystatin (disrupts caveolar structure and function; Enzo Life Sciences International, Inc.); 200 mM genistein (disrupts caveolae-mediated PLOS Pathogens | www.plospathogens.org 15 July 2013 | Volume 9 | Issue 7 | e1003463 endocytosis; Enzo Life Sciences International, Inc.), 100 mM Rac1 inhibitor (Rho GTPase inhibitor; Enzo Life Sciences International, Inc.) and 50 mM dynasore (dynamin inhibitor; Enzo Life Sciences International, Inc.) were added 1 h prior to HCMV infection at 37uC with 5% CO2. ..

    Article Title: The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes
    Article Snippet: Primary human mammary epithelial cells (HMEC) were culture in EBM-2 Basal Medium (Cambrex Inc., East Rutherford, NJ). .. The following standard treatment groups were employed in our study: dimethyl sulfoxide (DMSO; Sigma-Aldrich Inc.) as a solvent control; 1 μM PP2 (Src tyrosine kinase inhibitor; EMB Biosciences, Inc.; La Jolla, CA); 1 μM AG1478 (EGFR tyrosine kinase inhibitor; EMB Biosciences, Inc.); 0.5 μM jasplakinolide (inducer of actin polymerization; Enzo Life Sciences International, Inc.; Plymouth Meeting, PA); 2.5 μM latrunculin A (inhibitor of actin polymerization; Enzo Life Sciences International, Inc.); 50 μg/ml nystatin (disrupts caveolar structure and function; Enzo Life Sciences International, Inc.); 200 μM genistein (disrupts caveolae-mediated endocytosis; Enzo Life Sciences International, Inc.), 100 μM Rac1 inhibitor (Rho GTPase inhibitor; Enzo Life Sciences International, Inc.) and 50 μM dynasore (dynamin inhibitor; Enzo Life Sciences International, Inc.) were added 1 h prior to HCMV infection at 37°C with 5% CO 2 . ..



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    dynamin 2 inhibitor (dynasore  (Enzo Biochem)
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    Enzo Biochem dynamin 2 inhibitor (dynasore
    Endocytosis mechanism of Ad in combination with HDACi: ( a ) U343 cells were pretreated with ( a ) <t>dynamin</t> <t>2</t> inhibitor (dynasore—40 μM), ( b ) clathrin inhibitor (CPZ—5 μM), or ( c ) caveolin inhibitor (genistein—37 μM) for 45 min. Subsequently, the cells were treated with dAd/GFP, dAd/GFP+SBHA, or dAd/GFP+MS-275. At 24 h post transduction, cells were analyzed for GFP expression by using the IncuCyte ® Live-Cell Analysis System (Sartorius). The data are representatives of three independent experiments performed in triplicate. Representative images are shown. Original magnification: ×40. Bars represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001.
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    DiI-VLDL uptake is abrogated by treatment with heparin or <t>Dynasore</t> across BC cell lines. A: Treatment with heparin (500 µg/ml) or Dynasore (80 µM) reduced DiI-VLDL uptake, as quantified by flow cytometry. Replicates from ≥3 experiments are shown (***P < 0.001; one-way ANOVA with correction for multiple comparisons). B: Effects of heparin (500 µg/ml) and Dynasore (80 µM) on Di-VLDL binding and uptake in adherent BC cells visualized by confocal microscopy. Heparin or Dynasore prevented both binding and internalization of DiI-VLDL particles at 37°C. Representative images shown: DiI-VLDL <t>(red),</t> <t>Hoechst</t> nuclear stain (blue).
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    Image Search Results


    Endocytosis mechanism of Ad in combination with HDACi: ( a ) U343 cells were pretreated with ( a ) dynamin 2 inhibitor (dynasore—40 μM), ( b ) clathrin inhibitor (CPZ—5 μM), or ( c ) caveolin inhibitor (genistein—37 μM) for 45 min. Subsequently, the cells were treated with dAd/GFP, dAd/GFP+SBHA, or dAd/GFP+MS-275. At 24 h post transduction, cells were analyzed for GFP expression by using the IncuCyte ® Live-Cell Analysis System (Sartorius). The data are representatives of three independent experiments performed in triplicate. Representative images are shown. Original magnification: ×40. Bars represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Journal: Cells

    Article Title: GM101 in Combination with Histone Deacetylase Inhibitor Enhances Anti-Tumor Effects in Desmoplastic Microenvironment

    doi: 10.3390/cells10112811

    Figure Lengend Snippet: Endocytosis mechanism of Ad in combination with HDACi: ( a ) U343 cells were pretreated with ( a ) dynamin 2 inhibitor (dynasore—40 μM), ( b ) clathrin inhibitor (CPZ—5 μM), or ( c ) caveolin inhibitor (genistein—37 μM) for 45 min. Subsequently, the cells were treated with dAd/GFP, dAd/GFP+SBHA, or dAd/GFP+MS-275. At 24 h post transduction, cells were analyzed for GFP expression by using the IncuCyte ® Live-Cell Analysis System (Sartorius). The data are representatives of three independent experiments performed in triplicate. Representative images are shown. Original magnification: ×40. Bars represent the mean ± SD. * P < 0.05, ** P < 0.01, *** P < 0.001.

    Article Snippet: U343 cells were pretreated with dynamin 2 inhibitor (dynasore—40 μM, Enzo Life Sciences, Farmingdale, NY, USA), clathrin inhibitor (CPZ—5 μM, Enzo Life Sciences), or caveolin inhibitor (genistein—37 μM, Enzo Life Sciences) for 45 min, along with PBS as a negative control.

    Techniques: Transduction, Expressing

    DiI-VLDL uptake is abrogated by treatment with heparin or Dynasore across BC cell lines. A: Treatment with heparin (500 µg/ml) or Dynasore (80 µM) reduced DiI-VLDL uptake, as quantified by flow cytometry. Replicates from ≥3 experiments are shown (***P < 0.001; one-way ANOVA with correction for multiple comparisons). B: Effects of heparin (500 µg/ml) and Dynasore (80 µM) on Di-VLDL binding and uptake in adherent BC cells visualized by confocal microscopy. Heparin or Dynasore prevented both binding and internalization of DiI-VLDL particles at 37°C. Representative images shown: DiI-VLDL (red), Hoechst nuclear stain (blue).

    Journal: Journal of Lipid Research

    Article Title: Endocytosis of very low-density lipoproteins: an unexpected mechanism for lipid acquisition by breast cancer cells [S]

    doi: 10.1194/jlr.RA119000327

    Figure Lengend Snippet: DiI-VLDL uptake is abrogated by treatment with heparin or Dynasore across BC cell lines. A: Treatment with heparin (500 µg/ml) or Dynasore (80 µM) reduced DiI-VLDL uptake, as quantified by flow cytometry. Replicates from ≥3 experiments are shown (***P < 0.001; one-way ANOVA with correction for multiple comparisons). B: Effects of heparin (500 µg/ml) and Dynasore (80 µM) on Di-VLDL binding and uptake in adherent BC cells visualized by confocal microscopy. Heparin or Dynasore prevented both binding and internalization of DiI-VLDL particles at 37°C. Representative images shown: DiI-VLDL (red), Hoechst nuclear stain (blue).

    Article Snippet: The following reagents were prepared as stock solutions in DMSO: GSK264220A, lipase inhibitor (50 mM; Cayman Chemical); Dynasore, inhibitor of dynamin 1 and 2 (80 mM; Sigma-Aldrich); and Hoechst 33342 nuclear stain (20 mM; Thermo Fisher Scientific).

    Techniques: Flow Cytometry, Binding Assay, Confocal Microscopy, Staining